Publications
Deep functional measurements of Fragile X Syndrome human neurons reveal multiparametric electrophysiological disease phenotype
Deep functional measurements of Fragile X Syndrome human neurons reveal multiparametric electrophysiological disease phenotype
James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Karthiayani Harikrishnan, Chris Hempel, Hansini Upadhyay, Trinh Nguyen, Himali Shroff, David Stoppel, Jane Jacques, Jennifer Grooms, Elizabeth Berry-Kravis, Mark F. Bear, Luis A. Williams, David Gerber, Mark Bunnage, Brinley Furey, Graham T. Dempsey Communications Biology. 2024 Nov; 7(1): 1447. doi: 10.1038/s42003-024-07120-6. PMID: 39506078.
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology
Liu PW, Zhang H, Werley CA, Pichler M, Ryan SJ, Lewarch CL, Jacques J, Grooms J, Ferrante J, Li G, Zhang D, Bremmer N, Barnett A, Chantre R, Elder AE, Cohen AE, Williams LA, Dempsey GT, McManus OB. Pain. 2024 April; 165(4):922-940. doi: 10.1097/j.pain.0000000000003090. PMID: 37963235
Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis
Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis
Luis A. Williams, Steven J. Ryan, Vaibhav Joshi, Caitlin Lewarch, Amy Elder, Owen McManus, Patrice Godard, Srinidhi Sridhar, Jane Jacques, Jennifer Grooms, James J. Fink, Hongkang Zhang, Michel Gillard, Cécile Pegurier, Yogesh Sabnis, Véronique André, Lucinda Steward, Stefanie Dedeurwaerdere, Orrin Devinsky, Christian Wolff, Graham T. Dempsey. bioRxiv 2024.02.22.581652;
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells
Borja GB, Zhang H, Harwood BN, Jacques J, Grooms J, Chantre RO, Zhang D, Barnett A, Werley CA, Lu Y, Nagle SF, McManus OB, Dempsey GT. Front Mol Neurosci. 2022 Jul 4;15:896320. doi: 10.3389/fnmol.2022.896320. eCollection 2022.
Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models
Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models
Williams LA, Gerber DJ, Elder A, Tseng WC, Baru V, Delaney-Busch N, Ambrosi C, Mahimkar G, Joshi V, Shah H, Harikrishnan K, Upadhyay H, Rajendran SH, Dhandapani A, Meier J, Ryan SJ, Lewarch C, Black L, Douville J, Cinquino S, Legakis H, Nalbach K, Behrends C, Sato A, Galluzzi L, Yu TW, Brown D, Agrawal S, Margulies D, Kopin A, Dempsey GT. Mol Ther Nucleic Acids. 2022 Jun 22;29:189-203. doi: 10.1016/j.omtn.2022.06.015. eCollection 2022 Sep 13
Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters
Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters
Borja GB, Shroff H, Upadhyay H, Liu PW, Baru V, Cheng YC, McManus OB, Williams LA, Dempsey GT, Werley CA. Methods Mol Biol. 2021;2191:109-134. doi: 10.1007/978-1-0716-0830-2_8. PMID: 32865742
