Decoding neurons to unlock breakthrough cns therapeutics

Mission

To accelerate discovery of empirically grounded, AI-driven therapeutics that deliver transformative value to patients with neurological disease - all powered through Quiver's innovation engine and strategic partnerships.

The opportunity

Brain health is a growing global crisis, but neurological drug development continues to see the lowest success rates. Most failures trace back to weak targets, unexpected toxicities, and misaligned patient selection—issues driven by the historical lack of scalable human-relevant models, reliable neural measurements, and the computational power needed to decode complex brain biology.

Quiver's Solution

Our value proposition is simple: safer, more effective CNS drugs, discovered faster and at lower cost, with human relevance built in from day one. Our approach integrates cutting-edge scalable biology, state-of-the-art technology and engineering, and learning and surrogate models to identify novel therapeutic targets and the best candidate molecules to deliver new and meaningful therapeutics to patients.

quiver purple, pink, and red brain
01
Models
Patient-derived stem-cell models enhance translatability by capturing disease phenotypes. In vitro assays are complemented by ex vivo tissue slice assays to probe 3D circuits
02
signals
All-optical electrophysiology that scalably assesses neuron function at the gold-standard resolution, but with >10,000x throughput 9.6B+ action potentials from >126M neurons and counting
03
insights
AI models mine our high-dimensional data to (a) establish disease phenotypes, (b) assess drug efficacy, (c) match drugs to targets, and (d) avoid unwanted, off-vector toxicity 
quiver purple, pink, and red brain

Quiver's Solution

Our value proposition is simple: safer, more effective CNS drugs, discovered faster and at lower cost, with human relevance built in from day one. Our approach integrates cutting-edge scalable biology, state-of-the-art technology and engineering, and learning and surrogate models to identify novel therapeutic targets and the best candidate molecules to deliver new and meaningful therapeutics to patients.

01
Models
Patient-derived stem-cell models enhance translatability by capturing disease phenotypes.
02
signals
All-optical electrophysiology that scalably assesses neuron function at the gold-standard resolution, but with >5,000x throughput 1B action potentials from >25M neurons in <6 months
03
insights
AI models mine our high-dimensional data to (a) establish disease phenotypes, (b) assess drug efficacy, (c) match drugs to targets, and (d) avoid unwanted, off-vector toxicity 

OUR PLATFORM-POWERED THERAPEUTIC PIPELINE

Development Stage
Partner
Platform Value Delivered
Target (Modality)
Indication
Discovery
Pre-clinical
Clinical
Wholly Owned
Identify the
best molecule (Efficacy/Toxicity)
Genetically-validated+
Nav1.7 (ASO)
Chronic Pain
DC in 1Q 26
UBE3A (ASO)
Dup15q syndrome
DC in 2Q 26
Nav1.8 (ASO)
Chronic Pain
STXBP1 (ASO)
DEE4
SYNGAP1 (ASO)
DEE*
Nav1.7 / 1.8 (dual ASO)
Chronic Pain
FMR1 (undisclosed)
FXS**
Identify target
and the best molecule
Novel
TSC2 (Small Molecule)
TSC***
Wholly Owned
New Target Discovery
Undisclosed Pharma #1‡
New Target Discovery
Undisclosed Pharma #2‡
*DEE: developmental and epileptic encephalopathy; **Fragile X Syndrome; ***Tuberous Sclerosis; +Excitatory/Inhibitory
+Additional early discovery programs not listed include: SCN8A ASO, Dual Nav1.7/1.8 ASO, Nav1.8 SM, Signed in Q4 2025
We welcome partnership opportunities with other organizations seeking to develop novel therapeutics for serious diseases or with parties interested in leveraging our unique platform capabilities
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